Statistics

====Experimental and observational studies====
A common goal for a statistical research project is to investigate [[causality]], and in particular to draw a conclusion on the effect of changes in the values of predictors or [[Dependent and independent variables|independent variables on dependent variables]]. There are two major types of causal statistical studies: [[Experiment|experimental studies]] and [[Observational study|observational studies]]. In both types of studies, the effect of differences of an independent variable (or variables) on the behavior of the dependent variable are observed. The difference between the two types lies in how the study is actually conducted. Each can be very effective.
An experimental study involves taking measurements of the system under study, manipulating the system, and then taking additional [[Level of measurement|measurements with different levels]] using the same procedure to determine if the manipulation has modified the values of the measurements. In contrast, an observational study does not involve [[Scientific control|experimental manipulation]]. Instead, data are gathered and correlations between predictors and response are investigated. While the tools of data analysis work best on data from [[Randomized controlled trial|randomized studies]], they are also applied to other kinds of data—like [[natural experiment]]s and [[Observational study|observational studies]]<ref>[[David A. Freedman (statistician)|Freedman, D.A.]] (2005) ''Statistical Models: Theory and Practice'', Cambridge University Press. {{isbn|978-0-521-67105-7}}</ref>—for which a statistician would use a modified, more structured estimation method (e.g., [[Difference in differences|difference in differences estimation]] and [[instrumental variable]]s, among many others) that produce [[consistent estimator]]s.

=====Experiments=====
The basic steps of a statistical experiment are:
# Planning the research, including finding the number of replicates of the study, using the following information:  preliminary estimates regarding the size of [[Average treatment effect|treatment effects]], [[alternative hypothesis|alternative hypotheses]], and the estimated [[experimental error|experimental variability]]. Consideration of the selection of experimental subjects and the ethics of research is necessary. Statisticians recommend that experiments compare (at least) one new treatment with a standard treatment or control, to allow an unbiased estimate of the difference in treatment effects.
# [[Design of experiments]], using [[blocking (statistics)|blocking]] to reduce the influence of [[confounding variable]]s, and [[randomized assignment]] of treatments to subjects to allow [[bias of an estimator|unbiased estimates]] of treatment effects and experimental error. At this stage, the experimenters and statisticians write the ''[[protocol (natural sciences)|experimental protocol]]'' that will guide the performance of the experiment and which specifies the'' primary analysis'' of the experimental data.
# Performing the experiment following the [[Protocol (natural sciences)|experimental protocol]] and [[analysis of variance|analyzing the data]] following the experimental protocol.
# Further examining the data set in secondary analyses, to suggest new hypotheses for future study.
# Documenting and presenting the results of the study.

Experiments on human behavior have special concerns. The famous [[Hawthorne study]] examined changes to the working environment at the Hawthorne plant of the [[Western Electric Company]]. The researchers were interested in determining whether increased illumination would increase the productivity of the [[assembly line]] workers. The researchers first measured the productivity in the plant, then modified the illumination in an area of the plant and checked if the changes in illumination affected productivity. It turned out that productivity indeed improved (under the experimental conditions). However, the study is heavily criticized today for errors in experimental procedures, specifically for the lack of a [[control group]] and [[double-blind|blindness]]. The [[Hawthorne effect]] refers to finding that an outcome (in this case, worker productivity) changed due to observation itself. Those in the Hawthorne study became more productive not because the lighting was changed but because they were being observed.<ref name="pmid17608932">{{cite journal |vauthors=McCarney R, Warner J, Iliffe S, van Haselen R, Griffin M, Fisher P |title=The Hawthorne Effect: a randomised, controlled trial |journal=BMC Med Res Methodol |volume=7|pages=30 |year=2007 |pmid=17608932 |pmc=1936999 |doi=10.1186/1471-2288-7-30 |issue=1 |doi-access=free }}</ref>

=====Observational study=====
An example of an observational study is one that explores the association between smoking and lung cancer. This type of study typically uses a survey to collect observations about the area of interest and then performs statistical analysis. In this case, the researchers would collect observations of both smokers and non-smokers, perhaps through a [[cohort study]], and then look for the number of cases of lung cancer in each group.<ref>{{cite book|editor1-last=Rothman|editor1-first=Kenneth J|editor2-last=Greenland|editor2-first=Sander|editor3-last=Lash|editor3-first=Timothy|title=Modern Epidemiology|url=https://archive.org/details/modernepidemiolo00roth|url-access=limited|date=2008|publisher=Lippincott Williams & Wilkins|page=[https://archive.org/details/modernepidemiolo00roth/page/n100 100]|edition=3rd|language=en|chapter=7|isbn=978-0781755641}}</ref> A [[case-control study]] is another type of observational study in which people with and without the outcome of interest (e.g. lung cancer) are invited to participate and their exposure histories are collected.