Fatigue

=== Heat shock proteins ===
A small 2016 study found that primary [[Sjögren's syndrome]] patients with high fatigue, when compared with those with low fatigue, had significantly higher plasma concentrations of [[Hsp90|HSP90α]], and a tendency to higher concentrations of HSP72.<ref>{{cite journal | pmc=4804286 | year=2016 | last1=Bårdsen | first1=K. | last2=Nilsen | first2=M. M. | last3=Kvaløy | first3=J. T. | last4=Norheim | first4=K. B. | last5=Jonsson | first5=G. | last6=Omdal | first6=R. | title=Heat shock proteins and chronic fatigue in primary Sjögren's syndrome | journal=Innate Immunity | volume=22 | issue=3 | pages=162–167 | doi=10.1177/1753425916633236 | pmid=26921255 }}</ref> A small 2020 study of Crohn's disease patients found that higher fatigue visual analogue scale (fVAS) scores correlated with hgher HSP90α levels.<ref name="pmid31601148">{{cite journal |last1=Grimstad |first1=Tore |last2=Kvivik |first2=Ingeborg |last3=Kvaløy |first3=Jan Terje |last4=Aabakken |first4=Lars |last5=Omdal |first5=Roald |title=Heat-shock protein 90 α in plasma reflects severity of fatigue in patients with Crohn's disease |journal=Innate Immunity |date=February 2020 |volume=26 |issue=2 |pages=146–151 |doi=10.1177/1753425919879988 |pmid=31601148 |pmc=7016405 }}</ref> A related small 2012 trial investigating if application of an IL-1 receptor antagonist ([[anakinra]]) would reduce fatigue in primary Sjögren's syndrome patients was inconclusive.<ref>{{cite journal |last1=Norheim |first1=Katrine Brække |last2=Harboe |first2=Erna |last3=Gøransson |first3=Lasse G. |last4=Omdal |first4=Roald |title=Interleukin-1 Inhibition and Fatigue in Primary Sjögren's Syndrome – A Double Blind, Randomised Clinical Trial |journal=PLOS ONE |date=10 January 2012 |volume=7 |issue=1 |pages=e30123 |doi=10.1371/journal.pone.0030123 |doi-access=free |pmid=22253903 |pmc=3254637 |bibcode=2012PLoSO...730123N }}</ref><ref>{{cite journal |last1=Omdal |first1=Roald |last2=Gunnarsson |first2=Ragnar |title=The effect of interleukin-1 blockade on fatigue in rheumatoid arthritis—a pilot study |journal=Rheumatology International |date=September 2005 |volume=25 |issue=6 |pages=481–484 |doi=10.1007/s00296-004-0463-z |pmid=15071755 }}</ref><ref>{{cite journal |last1=Skoie |first1=Inger Marie |last2=Bårdsen |first2=Kjetil |last3=Nilsen |first3=Mari M. |last4=Eidem |first4=Live E. |last5=Grimstad |first5=Tore |last6=Dalen |first6=Ingvild |last7=Omdal |first7=Roald |title=Fatigue and expression of heat-shock protein genes in plaque psoriasis |journal=Clinical and Experimental Dermatology |date=June 2022 |volume=47 |issue=6 |pages=1068–1077 |doi=10.1111/ced.15068 |pmid=34921435 }}</ref>