Perfume

===Carcinogenicity===
There is scientific evidence that nitro-musks such as [[musk xylene]] could cause cancer in some specific animal tests. These reports were evaluated by the EU Scientific Committee for Consumer Safety (SCCS, formerly the SCCNFP<ref>{{cite web|url=http://ec.europa.eu/health/scientific_committees/consumer_safety/index_en.htm|title=Scientific Committee on Consumer Safety (SCCS) - Public Health - European Commission|website=Ec.europa.eu|access-date=19 February 2018|archive-date=22 November 2016|archive-url=https://web.archive.org/web/20161122065430/http://ec.europa.eu/health/scientific_committees/consumer_safety/index_en.htm|url-status=live}}</ref>) and musk xylene was found to be safe for continued use in cosmetic products.<ref>{{cite web|url=http://ec.europa.eu/health/ph_risk/committees/sccp/documents/out280_en.pdf|title=OPINION OF THE SCIENTIFIC COMMITTEE ON COSMETIC PRODUCTS AND NON-FOOD PRODUCTS INTENDED FOR CONSUMERS CONCERNING MUSK XYLENE AND MUSK KETONE|website=Ec.europa.eu|access-date=4 September 2019|archive-date=28 October 2020|archive-url=https://web.archive.org/web/20201028161257/https://ec.europa.eu/health/ph_risk/committees/sccp/documents/out280_en.pdf|url-status=live}}</ref> It is in fact part of the procedures of the Cosmetic Regulation in Europe that materials classified as carcinogens require such a safety evaluation by the authorities to be allowed in cosmetic consumer products.

Although other ingredients such as polycyclic [[synthetic musk]]s, have been reported to be positive in some in-vitro hormone assays,<ref>{{cite journal |vauthors=Schreurs RH, Legler J, Artola-Garicano E, etal |title=In vitro and in vivo antiestrogenic effects of polycyclic musks in zebrafish |journal=Environ. Sci. Technol. |volume=38 |issue=4 |pages=997–1002 |date=February 2004 |pmid=14998010 |doi=10.1021/es034648y |bibcode=2004EnST...38..997S |s2cid=8660062 |url=https://research.vu.nl/ws/files/1949128/163484.pdf |access-date=2 October 2019 |archive-date=25 February 2021 |archive-url=https://web.archive.org/web/20210225201417/https://research.vu.nl/ws/files/1949128/163484.pdf |url-status=live }}</ref><ref>{{cite journal |vauthors=Schreurs RH, Sonneveld E, Jansen JH, Seinen W, van der Burg B |title=Interaction of polycyclic musks and UV filters with the estrogen receptor (ER), androgen receptor (AR), and progesterone receptor (PR) in reporter gene bioassays |journal=Toxicol. Sci. |volume=83 |issue=2 |pages=264–72 |date=February 2005 |pmid=15537743 |doi=10.1093/toxsci/kfi035 |doi-access=free }}</ref> these reports have been reviewed by various authorities. For example, for one of the main polycyclic musks [[Galaxolide|Galaxolide (HHCB)]] these reviews include those of the EU Scientific Committee on Consumer Safety,<ref>{{cite web |url=http://ec.europa.eu/health/ph_risk/committees/sccp/documents/out179_en.pdf |title=Opinion on hhcb |website=Ec.europa.eu |access-date=17 February 2019 |archive-date=5 March 2022 |archive-url=https://web.archive.org/web/20220305160030/http://ec.europa.eu/health/ph_risk/committees/sccp/documents/out179_en.pdf |url-status=live }}</ref> the EU's Priority Substances Review,<ref>{{cite web|url=http://echa.europa.eu/documents/10162/947def3b-bbbf-473b-bc19-3bda7a8da910|title=European Union Risk Assessment Report : 1,3,4,6,7,8-HEXAHYDRO-4,6,6,7,8,8-HEXAMETHYLCYCLOPENTA-γ-2-BENZOPYRAN (1,3,4,6,7,8-HEXAHYDRO-4,6,6,7,8,8-HEXAMETHYLIN-DENO[5,6-C]PYRAN - HHCB)|website=Echa.europa.eu|access-date=4 September 2019|archive-date=19 January 2022|archive-url=https://web.archive.org/web/20220119013540/https://echa.europa.eu/documents/10162/947def3b-bbbf-473b-bc19-3bda7a8da910|url-status=live}}</ref> the EU Scientific Committee on Health and Environmental Risk,<ref>{{cite web|url=http://ec.europa.eu/health/ph_risk/committees/04_scher/docs/scher_o_086.pdf|title=Scientific Committee on Health and Environmental Risks : SCHER Opinion on Risk Assessment Report on 1,3,4,6,7,8-HEXAHYDRO4,6,6,7,8,8-HEXAMETHYLCYCLOPENTA-γ-2-BENZOPYRAN (HHCB) Human Health Part|website=Ec.europa.eu|access-date=4 September 2019|archive-date=16 August 2021|archive-url=https://web.archive.org/web/20210816172515/http://ec.europa.eu/health/ph_risk/committees/04_scher/docs/scher_o_086.pdf|url-status=live}}</ref> and more recently also the US EPA.<ref>{{cite web|url=http://www.epa.gov/oppt/existingchemicals/pubs/workplans.html|title=TSCA Work Plan Chemicals - Existing Chemicals - OPPT - US EPA<!-- Bot generated title -->|website=Epa.gov|date=29 April 2015|access-date=19 February 2018|archive-date=1 September 2015|archive-url=https://web.archive.org/web/20150901131114/http://www.epa.gov/oppt/existingchemicals/pubs/workplans.html|url-status=live}}</ref> The outcome of all of these reviews over the past decade or so is that there are no safety concerns for human health. Reviews with similar positive outcomes also exist for another main polycyclic musk (AHTN)—for instance, on its safe use in cosmetics by the EU.<ref>{{cite web |url=http://ec.europa.eu/health/ph_risk/committees/sccp/documents/out176_en.pdf |title=Opinion on ahtn |website=Ec.europa.eu |access-date=17 February 2019 |archive-date=21 July 2018 |archive-url=https://web.archive.org/web/20180721105737/http://ec.europa.eu/health/ph_risk/committees/sccp/documents/out176_en.pdf |url-status=live }}</ref>

Many natural aromatics, such as oakmoss absolutes,<ref name=udgiv/><ref name="OakAranol">{{cite journal  |vauthors=Rastogi SC, Bossi R, Johansen JD, etal |title=Content of oak moss allergens atranol and chloroatranol in perfumes and similar products |journal=Contact Derm. |volume=50 |issue=6 |pages=367–70 |date=June 2004 |pmid=15274728 |doi=10.1111/j.0105-1873.2004.00379.x |s2cid=38375267 }}</ref> [[basil]] oil, [[rose oil]] and many others contain allergens or carcinogenic compounds, the safety of which is either governed by regulations (e.g. allowed methyl eugenol levels in the EU Cosmetics Regulation (Entry{{nbsp}}102, Annex{{nbsp}}III of the EU Cosmetics Regulation.<ref>{{cite web|url=http://eur-lex.europa.eu/LexUriServ/LexUriServ.do?uri=CONSLEG:2009R1223:20130711:en:PDF|format=PDF|title=B REGULATION (EC) No 1223/2009 OF THE EUROPEAN PARLIAMENT AND OF THE COUNCIL of 30 November 2009 on cosmetic products|website=Eur-lex.europa.eu|access-date=4 September 2019|archive-date=3 October 2018|archive-url=https://web.archive.org/web/20181003061845/https://eur-lex.europa.eu/LexUriServ/LexUriServ.do?uri=CONSLEG:2009R1223:20130711:en:PDF|url-status=live}}</ref>) or through various limitations set by the International Fragrance Association.<ref>{{cite web|url=http://www.ifraorg.org/en-us/standards|title=standards - IFRA International Fragrance Association - in every sense|website=Ifraorg.org|access-date=19 February 2018|archive-date=1 March 2018|archive-url=https://web.archive.org/web/20180301073257/http://www.ifraorg.org/en-us/standards|url-status=live}}</ref>