COVID-19 Warning: You are not logged in. Your IP address will be publicly visible if you make any edits. If you log in or create an account, your edits will be attributed to your username, along with other benefits.Anti-spam check. Do not fill this in! === Pathology === The main pathological findings at autopsy are: * [[macroscopic scale|Macroscopy]]: [[pericarditis]], [[lung consolidation]] and [[pulmonary edema|pulmonary oedema]]<ref name="Cureus" /> * Lung findings: ** minor serous [[Exudate|exudation]], minor [[fibrin]] exudation<ref name="Cureus" /> ** pulmonary oedema, [[pneumocyte]] [[hyperplasia]], large atypical [[pneumocyte]]s, interstitial [[inflammation]] with [[lymphocytic]] [[Infiltration (medical)|infiltration]] and [[giant cell|multinucleated giant cell]] formation<ref name="Cureus" /> ** [[diffuse alveolar damage]] (DAD) with diffuse [[Pulmonary alveolus|alveolar]] [[exudates]]. DAD is the cause of [[acute respiratory distress syndrome]] (ARDS) and severe [[hypoxemia|hypoxaemia]].<ref name="Cureus" /> ** [[healing|organisation]] of [[exudate]]s in [[Pulmonary alveolus|alveolar cavities]] and [[Pulmonary fibrosis|pulmonary interstitial fibrosis]]<ref name="Cureus" /> ** [[plasma cell|plasmocytosis]] in [[bronchoalveolar lavage]] (BAL)<ref>{{#invoke:cite journal || vauthors = Giani M, Seminati D, Lucchini A, Foti G, Pagni F | title = Exuberant Plasmocytosis in Bronchoalveolar Lavage Specimen of the First Patient Requiring Extracorporeal Membrane Oxygenation for SARS-CoV-2 in Europe | journal = Journal of Thoracic Oncology | volume = 15 | issue = 5 | pages = e65βe66 | date = May 2020 | pmid = 32194247 | pmc = 7118681 | doi = 10.1016/j.jtho.2020.03.008 }}</ref> * Blood and vessels: [[disseminated intravascular coagulation]] (DIC);<ref>{{#invoke:cite journal || vauthors = Lillicrap D | title = Disseminated intravascular coagulation in patients with 2019-nCoV pneumonia | journal = Journal of Thrombosis and Haemostasis | volume = 18 | issue = 4 | pages = 786β787 | date = April 2020 | pmid = 32212240 | pmc = 7166410 | doi = 10.1111/jth.14781 }}</ref> leukoerythroblastic reaction,<ref>{{#invoke:cite journal || vauthors = Mitra A, Dwyre DM, Schivo M, Thompson GR, Cohen SH, Ku N, Graff JP | title = Leukoerythroblastic reaction in a patient with COVID-19 infection | journal = American Journal of Hematology | volume = 95 | issue = 8 | pages = 999β1000 | date = August 2020 | pmid = 32212392 | pmc = 7228283 | doi = 10.1002/ajh.25793 | title-link = doi | doi-access = free }}</ref> [[endotheliitis]],<ref name="SatturwarFowkes2021">{{#invoke:cite journal || vauthors = Satturwar S, Fowkes M, Farver C, Wilson AM, Eccher A, Girolami I, Pujadas E, Bryce C, Salem F, El Jamal SM, Paniz-Mondolfi A, Petersen B, Gordon RE, Reidy J, Fraggetta F, Marshall DA, Pantanowitz L | title = Postmortem Findings Associated With SARS-CoV-2: Systematic Review and Meta-analysis | journal = The American Journal of Surgical Pathology | volume = 45 | issue = 5 | pages = 587β603 | date = May 2021 | pmid = 33481385 | doi = 10.1097/PAS.0000000000001650 | pmc = 8132567 | s2cid = 231679276 }}</ref> [[hemophagocytosis]]<ref name="SatturwarFowkes2021" /> * Heart: [[cardiac muscle cell]] necrosis<ref name="SatturwarFowkes2021" /> * Liver: microvesicular [[steatosis]]<ref name="Cureus" /> * Nose: [[Impact of COVID-19 on neurological, psychological and other mental health outcomes|shedding of olfactory epithelium]]<ref name="Meunier-2020" /> * Brain: [[Cerebral infarction|infarction]]<ref name="SatturwarFowkes2021" /> * Kidneys: acute tubular damage.<ref name="SatturwarFowkes2021" /> * Spleen: [[white pulp]] depletion.<ref name="SatturwarFowkes2021" /> Summary: Please note that all contributions to Christianpedia may be edited, altered, or removed by other contributors. If you do not want your writing to be edited mercilessly, then do not submit it here. You are also promising us that you wrote this yourself, or copied it from a public domain or similar free resource (see Christianpedia:Copyrights for details). Do not submit copyrighted work without permission! Cancel Editing help (opens in new window) Discuss this page