Fatigue

===By effect===

Fatigue can have significant negative impacts on quality of life.<ref>{{cite journal |last1=Hemmett |first1=L. |last2=Holmes |first2=J. |last3=Barnes |first3=M. |last4=Russell |first4=N. |title=What drives quality of life in multiple sclerosis? |journal=QJM |date=October 2004 |volume=97 |issue=10 |pages=671–676 |doi=10.1093/qjmed/hch105 |pmid=15367738 |doi-access=free }}</ref><ref>{{cite journal | pmc=8267792 | year=2021 | last1=Mæland | first1=E. | last2=Miyamoto | first2=S. T. | last3=Hammenfors | first3=D. | last4=Valim | first4=V. | last5=Jonsson | first5=M. V. | title=Understanding Fatigue in Sjögren's Syndrome: Outcome Measures, Biomarkers and Possible Interventions | journal=Frontiers in Immunology | volume=12 | page=703079 | doi=10.3389/fimmu.2021.703079 | pmid=34249008 | doi-access=free }}</ref> Profound and debilitating fatigue is the most common complaint reported among individuals with autoimmune disease, such as systemic lupus erythematosus, multiple sclerosis, type 1 diabetes, celiac disease, [[Myalgic encephalomyelitis/chronic fatigue syndrome|Myalgic Encephalomyelitis/chronic fatigue syndrome]], and rheumatoid arthritis.<ref name="pmid34599320" />

Fatigue has been described by sufferers as 'incomprehensible' due to its unpredictable occurrence, lack of relationship to physical effort and different character as compared to tiredness.<ref>{{Cite journal|title=I've lost the person I used to be— Experiences of the consequences of fatigue following myocardial infarction|first1=Ulla|last1=Fredriksson-Larsson|first2=Pia|last2=Alsen|first3=Eva|last3=Brink|date=January 21, 2013|journal=International Journal of Qualitative Studies on Health and Well-being|volume=8|issue=1|pages=20836|doi=10.3402/qhw.v8i0.20836|pmid=23769653|pmc=3683631}}</ref> 

Fatigue that dissociates by quantum with disease activity represents a large health economic burden and unmet need to patients and to society.<ref name="pmid34599320" />