Mumps

==Immune response==
Even though MuV has just one serotype, significant variation in the quantity of genotype-specific sera needed to neutralize different genotypes ''in vitro'' has been observed.<ref name=latner /><ref name=beleni >{{cite journal |vauthors=Beleni AI, Borgmann S |date=31 July 2018 |title=Mumps in the Vaccination Age: Global Epidemiology and the Situation in Germany |journal=Int J Environ Res Public Health |volume=15 |issue=8 |pages=1618 |doi=10.3390/ijerph15081618 |pmc=6121553 |pmid=30065192 |doi-access=free }}</ref> Neutralizing antibodies in the salivary glands may be important in restricting MuV replication and transmission via saliva, as the level of viral secretion in saliva inversely correlates to the quantity of MuV-specific [[Immunoglobulin A|IgA]] produced.<ref name=su /> The neutralizing ability of salivary IgA appears to be greater than serum [[Immunoglobulin G|IgG]] and [[Immunoglobulin M|IgM]].<ref name=kutty />

It has been proposed that symptomatic infections in the vaccinated may be because [[Memory T cell|memory T lymphocytes]] generated as a result of vaccination may be necessary but insufficient for protection. The immune system in general appears to have a relatively weak response to the mumps virus, indicated by various measures: antibody production appears to be predominately directed toward non-neutralizing viral proteins, and there may possibly be a low quantity of MuV-specific [[Memory B cell|memory B lymphocytes]]. The amount of antibodies needed to confer immunity is unknown.<ref name=latner />
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