Tuberculosis Warning: You are not logged in. Your IP address will be publicly visible if you make any edits. If you log in or create an account, your edits will be attributed to your username, along with other benefits.Anti-spam check. Do not fill this in! === New onset === The recommended treatment of new-onset pulmonary tuberculosis, {{as of|2010|lc=yes}}, is six months of a combination of antibiotics containing rifampicin, isoniazid, [[pyrazinamide]], and [[ethambutol]] for the first two months, and only rifampicin and isoniazid for the last four months.<ref name=Lancet11/> Where resistance to isoniazid is high, ethambutol may be added for the last four months as an alternative.<ref name="Lancet11" /> Treatment with anti-TB drugs for at least 6 months results in higher success rates when compared with treatment less than 6 months, even though the difference is small. Shorter treatment regimen may be recommended for those with compliance issues.<ref name="Gelband_1999">{{cite journal | vauthors = Gelband H | title = Regimens of less than six months for treating tuberculosis | journal = The Cochrane Database of Systematic Reviews | issue = 2 | pages = CD001362 | date = 25 October 1999 | volume = 1999 | pmid = 10796641 | pmc = 6532732 | doi = 10.1002/14651858.CD001362 | collaboration = Cochrane Infectious Diseases Group }}</ref> There is also no evidence to support shorter anti-tuberculosis treatment regimens when compared to a 6-month treatment regimen.<ref>{{cite journal | vauthors = Grace AG, Mittal A, Jain S, Tripathy JP, Satyanarayana S, Tharyan P, Kirubakaran R | title = Shortened treatment regimens versus the standard regimen for drug-sensitive pulmonary tuberculosis | journal = The Cochrane Database of Systematic Reviews | volume = 12 | pages = CD012918 | date = December 2019 | issue = 12 | pmid = 31828771 | pmc = 6953336 | doi = 10.1002/14651858.CD012918.pub2 | collaboration = Cochrane Infectious Diseases Group }}</ref> However recently, results from an international, randomized, controlled clinical trial indicate that a four-month daily treatment regimen containing high-dose, or "optimized", rifapentine with moxifloxacin (2PHZM/2PHM) is as safe and effective as the existing standard six-month daily regimen at curing drug-susceptible tuberculosis (TB) disease.<ref>{{cite web |title=Landmark TB Trial Identifies Shorter-Course Treatment Regimen |url=https://www.cdc.gov/nchhstp/newsroom/2020/landmark-tb-trial-media-statement.html |website=CDC |date=20 October 2020 |publisher=NCHHSTP Media Team Centers for Disease Control and Prevention |access-date=27 November 2021 |archive-date=27 November 2021 |archive-url=https://web.archive.org/web/20211127171700/https://www.cdc.gov/nchhstp/newsroom/2020/landmark-tb-trial-media-statement.html |url-status=live }}</ref> Summary: Please note that all contributions to Christianpedia may be edited, altered, or removed by other contributors. If you do not want your writing to be edited mercilessly, then do not submit it here. You are also promising us that you wrote this yourself, or copied it from a public domain or similar free resource (see Christianpedia:Copyrights for details). Do not submit copyrighted work without permission! Cancel Editing help (opens in new window) Discuss this page